Pharmaceutical Crystal Engineering for Solid-State Design and Scale-Up

Designing stable and effective pharmaceutical solids requires a deep understanding of molecular arrangement and crystallization processes. This course introduces you to the essential principles of crystal engineering, helping you bridge the gap between molecular design and industrial-scale manufacturing. You will learn how to manipulate solid-state properties to improve drug solubility, stability, and bioavailability. Through written explanations and practical examples, you will explore modern crystallization techniques, solid-state characterization methods, and the engineering challenges of scaling up manufacturing processes. What you'll learn: Understand the fundamentals of polymorphism, solvates, and co-crystals in drug development; Analyze solid-state forms using modern characterization techniques like PXRD, DSC, and spectroscopic methods; Design crystallization processes that control particle size, morphology, and purity; Apply scale-up principles to transition crystallization from laboratory scale to industrial production; Implement modern Process Analytical Technology (PAT) to monitor and control crystallization in real time. The course begins with foundational definitions of crystal structures and solid-state chemistry before moving into practical crystallization design and engineering scale-up strategies. Designed for beginners in pharmaceutical sciences, chemical engineering, or chemistry, with no prior experience in crystal engineering required. Start reading to master the fundamentals of pharmaceutical solid-state design.